Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane; the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms; especially in the development of inflammatory pain.
Sequence
MAMLPPPGPQSFVRFTKQSLALIEQRIAEGKTKEPKEEKKDDHDEGPKPSSDLEAGKQLPFIYGDIPAGMVSEPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYILSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPAEWTKNVEYTFTGIYTFESLVKIFARGFCVGEFTFLRDPWNWLDFIVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVIILTVFCLSVFALIGLQLFMGHLKHKCLRKIENETLESIMSSIESEEDYKKYFYYLEGSKDALLCGFSTDSGQCPEGYYCVKAGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIGRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDDEKLSKSESEESISRKQFHLGVEGHRLAREKRLSAPNQSPLSIRGSLFSARRSSRTSLFSFKGRGKDIGSETEFADDEHSIFGDNESRRGSLFVPQRPQERRSSNLSQASRSPPMLQMNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTQIRKKRRSSSYLLSEDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPSWWYRFAHTFLIWNCSPFWIKFKKFIYIIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLVVGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNVFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGPLGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCSLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLSAIEEDTDANNLQIAVTRIKKGINYVKQTLRELILKAFSKKPKISKEIRQAEDLNSKKENYISNRTLAEMSKDYNFHKEKDKISGFGSSMDKYLMEESDHQSFIHNPSLTVTVPIAPGESDLENMNTEELSSDSESEYSKERLNRSSSSECSTVDNALPGEGEEAEAEPVNSDEPEACFTDGCVRRFPCCQVSIESGKGKIWWNIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYQCVNTTDDSRFPTKQVSNRSECFALMNGSQNVRWKNLKVNFDNVGLRYLSLLQVATFKGWMDIMYAAVDSVNVDQQPSYEHNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFDLVTNQAFDITIMILICLNMVTMMVEKEGQSDYMTDVLYWINVVFIILFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIETYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSTEGDCGSPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEYSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKEGDKDDDLPNKGDIVFDNVNSSSPEKTDATASTISPPSYDSVTKPDKEKYEKDKTEKEDKGKDGKETKK